Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules
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چکیده
منابع مشابه
Allele-Independent Turnover of Human Leukocyte Antigen (HLA) Class Ia Molecules
Major histocompatibility complex class I (MHCI) glycoproteins present cytosolic peptides to CD8+ T cells and regulate NK cell activity. Their heavy chains (HC) are expressed from up to three MHC gene loci (human leukocyte antigen [HLA]-A, -B, and -C in humans), whose extensive polymorphism maps predominantly to the antigen-binding groove, diversifying the bound peptide repertoire. Codominant ex...
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Radiotherapy (RT) has been employed for the treatment of oncological patients for nearly a century, and is presently considered as one of the most successful components of antineoplastic treatments [1-3]. Indeed, more than 50% of tumors received radiotherapy, alone or associated with chemo or immunotherapy [4]. The ability of RT to kill cancer cells by a direct cytotoxic mechanism has been well...
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Background: During pregnancy, the maternal immune system is in close contact with cells and tissue from the semiallogenic fetus .The Human Leucocyte Antigen (HLA) class Ib molecules, HLA-E, -F and -G, are expressed at the materno-fetal interface. Because of the apparent immunoregulatory functions of these proteins, they may be involved in successful acceptance of the semi-allogenic fetus during...
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The transporters associated with antigen processing (TAP) allow the supply of peptides derived from the cytosol to translocate to the endoplasmic reticulum, where they complex with nascent human leukocyte antigen (HLA) class I molecules. However, infected and tumor cells with TAP molecules blocked or individuals with non-functional TAP complexes are able to present HLA class I ligands generated...
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ژورنال
عنوان ژورنال: PLOS ONE
سال: 2016
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0161011